Tumor infiltrating lymphocytes (TIL)

The science of TIL

White blood cells perform immunosurveillance as they circulate throughout the body. They search for and eliminate foreign pathogens such as bacteria, viruses, or cancer cells.

TIL are part of the body’s normal immune response. They are white blood cells that have recognized a tumor during immunosurveillance and migrated from the bloodstream into the tumor. Once the TIL have infiltrated the tumor, they can recognize and begin to destroy cancer cells.1

In TIL therapy, a patient's TIL are extracted, isolated, amplified, and rejuvenated. Billions of TIL are then reinfused back into the patient. TIL are being investigated as a cellular immunotherapy because clinical studies have shown that they can recognize and help eradicate tumor cells.1

Reference: 1. Fardis M, DiTrapani K, Chartier C, Finckenstein FG. Current and future directions for tumor infiltrating lymphocyte therapy for the treatment of solid tumors. Cell Gene Ther Insights. 2020;6(6):855-863.